Just like the dentist tells you, "Don't ignore them." Check the fluid level and condition periodically, repair any leaks/problems promptly, service the unit on a regular basis, and add an auxiliary cooler if the vehicle is used for towing, commercial, or high ambient temperature climates. Some units should have a shift kit installed.
Synthetic fluid may benefit some applications by lowering operating temperature resulting in a longer life, but not all transmissions can use the synthetic fluid.. Check with us for your specific application and needs.